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There are several matches for 'fatty acid hydroxylase'.
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9511 matches
showing page 1 of 476
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organism
protein
1)
Homo sapiens
FA2H -
Fatty
acid
2-
hydroxylase
; Catalyzes the hydroxylation of free
fatty
acids
at the C-2 position to produce 2-hydroxy
fatty
acids
, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2- hydroxy
fatty
acids
. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in th [...]
[a.k.a. XM_011523317.3, R-HSA-556833, J3QS89,
fatty acid hydroxylase
]
2)
Homo sapiens
CYP4V2 - Cytochrome P450 4V2; Omega-
hydroxylase
that oxidizes medium-chain saturated
fatty
acids
and polyunsaturated omega-3
fatty
acids
, and which plays a role in
fatty
acid
and steroid metabolism in the eye. Catalyzes the omega-hydroxylation of medium-chain saturated
fatty
acids
such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3
fatty
acids
hydroxylase
by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21- [...]
[a.k.a. BAC85487.1, R-HSA-388396, CYP4V2-203]
3)
Homo sapiens
CYP2U1 - Cytochrome P450 2U1; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic
acid
and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Acts as an omega and omega-1
hydroxylase
for arachidonic
acid
and possibly for other long chain
fatty
acids
. May modulate the arachidonic
acid
signaling pathway and play a role in other
fatty
acid
signaling processes. May downregulat [...]
[a.k.a. R-HSA-211958, ENSP00000373598, R-HSA-556833]
4)
Homo sapiens
CYP4F2 - Cytochrome P450 4F2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including
fatty
acids
, eicosanoids and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain
fatty
acids
. Displays high omega-
hydroxylase
activity toward polyunsaturated
fatty
[...]
[a.k.a. 8529, AK300961, ENST00000221700.10]
5)
Homo sapiens
FAXDC2 -
Fatty
acid
hydroxylase
domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.
[a.k.a. ENSG00000170271, ENSP00000320604, ENST00000520968]
6)
Homo sapiens
CYP4X1 - Cytochrome P450 4X1; A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no
hydroxylase
activity toward various
fatty
acids
, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
[a.k.a. ENSG00000186377, AK131355, Cytochrome P450 4X1]
7)
Homo sapiens
CYP1B1 - Cytochrome P450 1B1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including
fatty
acids
, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant
hydroxylase
activity towar [...]
[a.k.a. Q16678, R-HSA-2142670, CYP1B1-201]
8)
Mus musculus
Cyp4v3 - Cytochrome P450 4V2; Omega-
hydroxylase
that oxidizes medium-chain saturated
fatty
acids
and polyunsaturated omega-3
fatty
acids
, and which plays a role in
fatty
acid
and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated
fatty
acids
such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3
fatty
acids
hydroxylase
by mediating oxidation of docosahexaenoate (DHA) to 22- hydroxydocosahexaenoate. Also produces some 2 [...]
[a.k.a. MGI:2142763, BC138967, 102294]
9)
Mus musculus
Fa2h -
Fatty
acid
2-
hydroxylase
; Catalyzes the hydroxylation of free
fatty
acids
at the C-2 position to produce 2-hydroxy
fatty
acids
, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy
fatty
acids
. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the [...]
[a.k.a. BC026400, Faxdc1, NM_178086.3]
10)
Mus musculus
Cyp2u1 - Cytochrome P450 2U1; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic
acid
and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1
hydroxylase
for arachidonic
acid
and possibly for other long chain
fatty
acids
. May modulate the arachidonic
acid
signaling pathway and play a role in other
fatty
acid
signaling processes. May downregulate [...]
[a.k.a. ENSMUST00000200236, ENSMUST00000200236.1, NP_082092.2]
11)
Mus musculus
Cyp4a12a - Cytochrome P450 4A12A; A cytochrome P450 monooxygenase involved in the metabolism of
fatty
acids
and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated
fatty
acids
. May act as a major omega-
hydroxylase
for dodecanoic (lauric)
acid
in kidney. Participates [...]
[a.k.a. Cyp4a12a-201, R-MMU-2142691, NP_803125]
12)
Mus musculus
Cyp4a12b - Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of
fatty
acids
and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated
fatty
acids
. May act as a major omega-
hydroxylase
for dodecanoic (lauric)
acid
in kidney. Participates [...]
[a.k.a. NM_172306.2, R-MMU-2142691, NP_758510.2]
13)
Mus musculus
Cyp4a14 - Cytochrome P450 4A14; A cytochrome P450 monooxygenase involved in the metabolism of
fatty
acids
. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of saturated carbon hydrogen bonds of
fatty
acids
. May act as a major omega- and ommega-1
hydroxylase
for dodecanoic (lauric)
acid
in kidney. Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic
acid
.
[a.k.a. CYPIVA14, R-MMU-2142691, XM_017319946.1]
14)
Mus musculus
Cyp4x1 - Cytochrome P450 4X1; A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no
hydroxylase
activity toward various
fatty
acids
, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
[a.k.a. Cytochrome P450 4X1, ENSMUSG00000047155, ENSMUSP00000102155]
15)
Drosophila melanogaster
fa2h -
Fatty
acid
2-
hydroxylase
; Catalyzes stereospecific hydroxylation of free
fatty
acids
at the C-2 position to produce (R)-2-hydroxy
fatty
acids
, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]
[a.k.a. FBgn0050502, fa2h-PB, CG1642]
16)
Drosophila melanogaster
CG11162 -
Fatty
acid
hydroxylase
domain-containing protein; C-4 methylsterol oxidase activity; oxidoreductase activity; iron ion binding. It is involved in the biological process described with: sterol biosynthetic process; oxidation-reduction process; Belongs to the sterol desaturase family.
[a.k.a. FBgn0030509, CG11162-PA, UPI000007D6BF]
17)
Caenorhabditis elegans
fath-1 -
Fatty
acid
2-
hydroxylase
; Catalyzes stereospecific hydroxylation of free
fatty
acids
at the C-2 position to produce (R)-2-hydroxy
fatty
acids
, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]
[a.k.a. C25A1.5, Q9XVS0, CE08370]
18)
Caenorhabditis elegans
F49E12.10 -
Fatty
acid
hydroxylase
domain-containing protein; Belongs to the sterol desaturase family.
[a.k.a. WBGene00009903, NP_495764, UPI0000080B8D]
19)
Caenorhabditis elegans
drd-1 -
Fatty
acid
hydroxylase
domain-containing protein; Belongs to the sterol desaturase family.
[a.k.a. F49E12.9a, F49E12.9b, 174339]
20)
Saccharomyces cerevisiae
SCS7 - Ceramide very long chain
fatty
acid
hydroxylase
SCS7; Sphingolipid alpha-
hydroxylase
; functions in the alpha-hydroxylation of sphingolipid-associated very long chain
fatty
acids
, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; Belongs to the sterol desaturase family. SCS7 subfamily.
[a.k.a. YMR272C, CAA89255.1, NP_013999.1]
9511 matches
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